British Air Force Typhoon FGR4s have joined forces with France's air force in a joint strike targeting an subterranean weapons facility in Syria employed by the IS group, according to the UK's MoD.
The site, pinpointed through surveillance, was believed to be housing weapons and explosive materials, the release indicated, and was located in mountainous terrain just above Palmyra in Syria's central region.
"The RAF jets used Paveway IV guided bombs to hit a several entry passages providing entry to the site... early reports are that the objective was successfully hit," the ministry announced.
There was no evidence of any civilian casualties in the operation on Saturday evening and all the aircraft made a safe return, the MoD added.
The Typhoon FGR4s were backed up by a Voyager tanker plane.
Daesh - also known as the so-called Islamic State - established jihadist rule over large swathes of Iraq and Syria until 2019.
"This strike demonstrates our UK leadership, and determination to operate in unison with allied nations, to eradicate any resurgence of IS and their dangerous and violent ideologies in the Middle East," the British Defence Secretary the Defence Secretary said.
UK warplanes have carried out overwatch operations over Syrian airspace to "deter any efforts to regroup" of the group following its military defeat at the Baghuz confrontation in 2019, the authorities noted.
"I extend gratitude to every member of British forces participating in this operation for their expertise and their courage," Healey said. "Including them were thousands of UK service members on duty over the holidays. This action, to remove dangerous terrorists who threaten our way of life, highlights how British military are ready to step up, all year round, ensuring Britain's security at home and powerful internationally."
During December, the United States armed forces conducted what it termed a "massive strike" on Islamic State objectives in Syria, following an attack resulted in the deaths of two American soldiers and a civilian linguist in the Palmyra area.
The United Nations says Daesh still boasts an estimated 5,000 to 7,000 militants in both countries.